Last time both sides met, East Kilbride left East Peffermill with all three points – thanks to a comprehensive 9-0 win.
East Kilbride currently sit top of the table with 63 points from their 25 games played – made up of 20 wins, three draws, and two defeats.
The Kilby are on a five-game winning streak in all competitions – including their dramatic 3-2 comeback against Tranent to extend their lead at the top of the league, midweek.
Edinburgh University currently sit bottom of the table with five points from their 25 games played – made up of one win, two draws, and 22 defeats.
Uni are on a nine-game losing streak in all competitions – conceding 41 goals and scoring six along the way.