The last four meetings between the two sides have been very entertaining – Edinburgh University have won twice, with both results ending 4-3, a 4-4 draw, and the last meeting saw East Kilbride win 6-1.
Edinburgh University sit bottom of the table, with only one point from seven games.
That point came last week – thanks to a 2-2 draw with Linlithgow Rose, breaking their losing streak of six straight defeats.
East Kilbride are flying at the top of the Lowland League, with 19 points from seven games.
The Kilby are the only team who have yet to deal with defeat, with six wins and a draw. They are also the top scorers – having scored 24 goals.