Berwick Rangers defeated Cowdenbeath 2-1 and 4-0 in the league last season. However, Cowdenbeath managed to knock them out of the Lowland League Cup, thanks to a 2-0 win.
Berwick Rangers currently find themselves in ninth place with 11 points.
The Wee Gers lost their opening two games, followed by two back-to-back draws, and come into this on the back of three consecutive victories.
Liam Buchanan of Berwick Rangers is currently the joint-top scorer, with eight goals from seven played.
Cowdenbeath sit in 11th place, two points behind Berwick Rangers – having picked up nine points from their six played.
The Blue Brazil come into this having suffered their first defeat of the season, 4-2 to East Kilbride, and will be looking to get back to picking up points again – with the form that saw them undefeated in five games.