Both sides faced each other last week – with East Kilbride knocking Cowdenbeath out of the South Challenge Cup thanks to a 6-0 win at Central Park.
Cowdenbeath currently sit in 10th place with 30 points from their 23 games played – made up of seven wins, nine draws, and seven defeats.
The Blue Brazil are without a competitive win in five games – losing four and drawing the other, including South Challenge and Lowland League Cup exits.
East Kilbride currently sit top of the table with 57 points from their 23 games played – made up of 18 wins, three draws, and two defeats.
The Kilby come into this with three wins on the bounce and have scored 12 goals along the way (conceding three), and will be hoping for a repeat performance of the 6-0 win at Central Park, last week.